Layer-specific BOLD activation in human V1
نویسندگان
چکیده
منابع مشابه
Layer specific BOLD activation in human V1 at 3 Tesla
Introduction Detection of neural responses at the laminar level in humans would significantly increase the scope and power of fMRI. To date this goal has proven elusive. In this study we demonstrate for the first time layer specific activation in humans, specifically in layer IV of V1. On the basis of this result and known blood-vessel distribution within V1 we conclude that for examinations pe...
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The laminar structure of the cortex has previously been explored both in non-human primates and human subjects using high-resolution functional magnetic resonance imaging (fMRI). However, whether the spatial specificity of the blood-oxygenation-level-dependent (BOLD) fMRI is sufficiently high to reveal lamina specific organization in the cortex reliably is still unclear. In this study we demons...
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Introduction In a study at 3 T [1] it was shown that visual stimulation led to a larger signal change in the granular layer than in the infraand supragranular layers of human primary visual cortex (V1). The underlying mechanism causing the response to simple stimulation to peak in this layer is unknown, but it is consistently found in animals as well [2-4] and shows that layer-specific effects ...
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With sufficient image encoding, high-resolution fMRI studies are limited by the biological point-spread of the hemodynamic signal. The extent of this spread is determined by the local vascular distribution and by the spatial specificity of blood flow regulation, as well as by measurement parameters that (i) alter the relative sensitivity of the acquisition to activation-induced hemodynamic chan...
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Blood oxygenation level-dependent (BOLD) fMRI signals often exhibit pronounced over- or undershoot upon changes in stimulation state. Current models postulate that this is due to the delayed onset or decay of perfusion-dependent attenuating responses such as increased cerebral blood volume or oxygen consumption, which are presumed to lag behind the rapid adjustment of blood flow rate to a new s...
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ژورنال
عنوان ژورنال: Human Brain Mapping
سال: 2010
ISSN: 1065-9471
DOI: 10.1002/hbm.20936